5c–d). CX-5461-mediated S33 phosphorylation of RPA was impartial in the cell cycle stage and wasn't limited towards the nucleoli in HR-deficient cells. As a result, the formation of ssDNA constructions in CX-5461 dealt with cells may result in replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication tensio

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