System of Motion: Obeticholic acid can be an agonist for Farnesoid X Receptor (FXR), a nuclear receptor expressed from the liver and intestine. FXR can be a important regulator of bile acid, inflammatory, fibrotic and metabolic pathways. FXR activation decreases the intracellular hepatocyte concentrations of bile acids by suppressing de novo synth

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 5c–d). CX-5461-mediated S33 phosphorylation of RPA was impartial in the cell cycle stage and wasn't limited towards the nucleoli in HR-deficient cells. As a result, the formation of ssDNA constructions in CX-5461 dealt with cells may result in replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication tensio